Pseudomonas aeruginosa UCBPP-PA14, PA14_11845 (mpl)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0071236 cellular response to antibiotic
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA4020
 ECO:0000249
sequence similarity evidence used in automatic assertion		 24041903
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF53623
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009058 biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02875
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0071555 cell wall organization
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_02020
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016881 acid-amino acid ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02875
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009252 peptidoglycan biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_02020
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other UCBPP-PA14 genes in this class
Antibiotic resistance and susceptibility Other UCBPP-PA14 genes in this class

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
NCBIfam TIGR01081 JCVI: UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase IPR005757 Murein peptide ligase 2 449 0.0
Gene3D G3DSA:3.40.50.720 - - - 1 90 2.3E-34
Gene3D G3DSA:3.40.1190.10 - IPR036565 Mur-like, catalytic domain superfamily 91 313 1.8E-70
Pfam PF08245 Mur ligase middle domain IPR013221 Mur ligase, central 108 291 3.5E-21
FunFam G3DSA:3.40.50.720:FF:000161 UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase - - 1 90 2.6E-55
SUPERFAMILY SSF53244 MurD-like peptide ligases, peptide-binding domain IPR036615 Mur ligase, C-terminal domain superfamily 311 448 5.49E-34
Hamap MF_02020 UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase [mpl]. IPR005757 Murein peptide ligase 1 450 60.768185
SUPERFAMILY SSF53623 MurD-like peptide ligases, catalytic domain IPR036565 Mur-like, catalytic domain superfamily 94 308 1.57E-52
Pfam PF02875 Mur ligase family, glutamate ligase domain IPR004101 Mur ligase, C-terminal 311 360 1.3E-8
PANTHER PTHR43445 UDP-N-ACETYLMURAMATE--L-ALANINE LIGASE-RELATED - - 2 450 1.0E-110
Gene3D G3DSA:3.90.190.20 - IPR036615 Mur ligase, C-terminal domain superfamily 314 451 3.6E-37
SUPERFAMILY SSF51984 MurCD N-terminal domain - - 1 90 1.57E-23
Pfam PF01225 Mur ligase family, catalytic domain IPR000713 Mur ligase, N-terminal catalytic domain 2 100 7.3E-22

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.