Pseudomonas aeruginosa UCBPP-PA14, PA14_12130 (lis)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009107 lipoate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF005963
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF04055
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051536 iron-sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF04055
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016992 lipoate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF005963
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF005963
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00785 Lipoic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PIRSF PIRSF005963 Lipoyl_synth IPR003698 Lipoyl synthase 6 327 4.5E-128
SFLD SFLDG01058 lipoyl synthase like - - 39 324 0.0
CDD cd01335 Radical_SAM - - 97 272 1.70947E-7
SMART SM00729 MiaB IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain 90 299 1.1E-13
Hamap MF_00206 Lipoyl synthase [lipA]. IPR003698 Lipoyl synthase 1 327 153.716309
FunFam G3DSA:3.20.20.70:FF:000023 Lipoyl synthase - - 87 298 4.9E-119
PANTHER PTHR10949 LIPOYL SYNTHASE IPR003698 Lipoyl synthase 40 322 1.7E-115
SFLD SFLDF00271 lipoyl synthase IPR003698 Lipoyl synthase 39 324 0.0
SUPERFAMILY SSF102114 Radical SAM enzymes - - 56 322 9.03E-68
Pfam PF04055 Radical SAM superfamily IPR007197 Radical SAM 97 256 1.2E-14
Pfam PF16881 N-terminal domain of lipoyl synthase of Radical_SAM family IPR031691 Lipoyl synthase, N-terminal 43 79 2.2E-7
NCBIfam TIGR00510 JCVI: lipoyl synthase IPR003698 Lipoyl synthase 38 321 2.9E-127
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 87 307 1.5E-19

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.