Pseudomonas aeruginosa UCBPP-PA14, PA14_47100 (ilvA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004794 L-threonine ammonia-lyase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01124
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009097 isoleucine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01124
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00290 Valine, leucine and isoleucine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00585 C-terminal regulatory domain of Threonine dehydratase IPR001721 Threonine dehydratase, ACT-like domain 330 420 2.8E-22
CDD cd04907 ACT_ThrD-I_2 - - 434 513 2.46795E-44
Gene3D G3DSA:3.40.50.1100 - IPR036052 Tryptophan synthase beta chain-like, PALP domain superfamily 65 156 2.9E-111
PANTHER PTHR48078 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED - - 24 513 0.0
Pfam PF00291 Pyridoxal-phosphate dependent enzyme IPR001926 Tryptophan synthase beta chain-like, PALP domain 30 317 1.1E-81
CDD cd01562 Thr-dehyd - - 17 321 0.0
FunFam G3DSA:3.40.50.1100:FF:000008 L-threonine dehydratase - - 141 311 6.1E-70
Gene3D G3DSA:3.40.50.1100 - IPR036052 Tryptophan synthase beta chain-like, PALP domain superfamily 32 311 2.9E-111
Gene3D G3DSA:3.40.1020.10 Biosynthetic Threonine Deaminase; Domain 3 IPR038110 Threonine dehydratase, ACT-like domain superfamily 339 514 1.2E-71
SUPERFAMILY SSF53686 Tryptophan synthase beta subunit-like PLP-dependent enzymes IPR036052 Tryptophan synthase beta chain-like, PALP domain superfamily 16 366 1.7E-103
SUPERFAMILY SSF55021 ACT-like IPR045865 ACT-like domain 421 513 2.75E-27
NCBIfam TIGR01124 JCVI: threonine ammonia-lyase, biosynthetic IPR005787 Threonine dehydratase, biosynthetic 16 513 0.0
CDD cd04906 ACT_ThrD-I_1 - - 339 423 1.79659E-40
FunFam G3DSA:3.40.1020.10:FF:000001 L-threonine dehydratase - - 339 515 9.0E-75
Pfam PF00585 C-terminal regulatory domain of Threonine dehydratase IPR001721 Threonine dehydratase, ACT-like domain 430 513 1.3E-25

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.