Pseudomonas aeruginosa UCBPP-PA14, PA14_01110 (vgrG1a)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 - Assembly GCF_000014625.1
Locus Tag
Replicon chromosome
Genomic location 108629 - 110560 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 48 transposon mutants in orthologs
CommentHcp Secretion Island-I-encoded type VI secretion system (H1-T6SS)


RefSeq YP_788248.1
GI 116053811
Entrez 4383509
NCBI Locus Tag PA14_01110


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -7.09
Kyte-Doolittle Hydrophobicity Value -0.538
Molecular Weight (kDa) 72041.1
Isoelectric Point (pI) 6.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4MTK TOXIN 09/19/13 Crystal structure of PA0091 VgrG1, the central spike of the Type VI Secretion System Pseudomonas aeruginosa 3.322 X-RAY DIFFRACTION 99.5
6H3L TOXIN 07/19/18 Structure of VgrG1 in the Type VI secretion pre-firing VgrG1-Tse6-EagT6-EF-Tu-Tsi6 complex Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 4.2 ELECTRON MICROSCOPY 99.5
6H3N TOXIN 07/19/18 Structure of VgrG1 in the Type VI secretion VgrG1-Tse6-EF-Tu complex embedded in lipid nanodiscs Pseudomonas aeruginosa PAO1 3.25 ELECTRON MICROSCOPY 99.5
4UHV STRUCTURAL PROTEIN 03/25/15 The structure of VgrG1, the needle tip of the bacterial Type VI Secretion System PSEUDOMONAS AERUGINOSA 2 X-RAY DIFFRACTION 99.5

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 156 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000090 (3404 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA14_01110
Search term: vgrG1a
Search term: VgrG1a

Human Homologs


Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins.
Hachani A, Lossi NS, Hamilton A, Jones C, Bleves S, Albesa-Jové D, Filloux A
J. Biol. Chem. 2011 Apr;286(14):12317-27
PubMed ID: 21325275
RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A.
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7707-7712.
PubMed ID: 28673999