Pseudomonas aeruginosa UCBPP-PA14, PA14_09450 (phzD1)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_09450
Name	phzD1
Replicon	chromosome
Genomic location	810256 - 810879 (- strand)
Transposon Mutants in orthologs	9 transposon mutants in orthologs

Cross-References

RefSeq	YP_788906.1
GI	116052250
Entrez	4385687
INSDC	ABJ13486.1
NCBI Locus Tag	PA14_09450
UniParc	UPI00000D422A
UniProtKB Acc	Q02T30
UniProtKB ID	Q02T30_PSEAB
UniRef100	UniRef100_Q7DC80
UniRef50	UniRef50_Q51790
UniRef90	UniRef90_Q7DC80

Product

Feature Type	CDS
Coding Frame	1
Product Name	phenazine biosynthesis protein PhzD
Synonyms
Evidence for Translation
Charge (pH 7)	-3.89
Kyte-Doolittle Hydrophobicity Value	-0.094
Molecular Weight (kDa)	23.2
Isoelectric Point (pI)	5.63

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
1NF8	HYDROLASE	12/13/02	Crystal structure of PhzD protein active site mutant with substrate	Pseudomonas aeruginosa	1.6	X-RAY DIFFRACTION	99.5
1NF9	HYDROLASE	12/13/02	Crystal Structure of PhzD protein from Pseudomonas aeruginosa	Pseudomonas aeruginosa	1.5	X-RAY DIFFRACTION	100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name	Source Accession	Source DB	Version	Target Accession	Target Description	Percent Identity	Alignment Length	E-Value
Isochorismic Acid	DB02793	DrugBank	5.1.4	Q7DC80	Phenazine biosynthesis protein PhzD	100.0	207	3.6e-116
Formic acid	DB01942	DrugBank	5.1.4	Q7DC80	Phenazine biosynthesis protein PhzD	100.0	207	3.6e-116

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 231 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001494 (1079 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_09450 Search term: phzD1 Search term: phenazine biosynthesis protein PhzD

Human Homologs

References