Pseudomonas aeruginosa UCBPP-PA14, PA14_20020 (hasAp)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_20020
Name	hasAp
Replicon	chromosome
Genomic location	1724698 - 1725315 (+ strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	YP_789741.1
GI	116051426
Entrez	4381372
INSDC	ABJ12662.1
NCBI Locus Tag	PA14_20020
UniParc	UPI00000D425A
UniProtKB Acc	Q02QP5
UniProtKB ID	Q02QP5_PSEAB
UniRef100	UniRef100_G3XD33
UniRef50	UniRef50_Q4K5N8
UniRef90	UniRef90_G3XD33

Product

Feature Type	CDS
Coding Frame	1
Product Name	heme acquisition protein HasAp
Synonyms
Evidence for Translation
Charge (pH 7)	-12.57
Kyte-Doolittle Hydrophobicity Value	0.063
Molecular Weight (kDa)	20.9
Isoelectric Point (pI)	4.13

Subcellular localization

Individual Mappings	Localization Confidence PMID Extracellular Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5XIE	TRANSPORT PROTEIN	04/26/17	Crystal Structure of HasAp with 5-ethynyl-10,20-diphenylporphyrin	Pseudomonas aeruginosa str. PAO1	2.05	X-RAY DIFFRACTION	100.0
5XKB	TRANSPORT PROTEIN	05/06/17	Crystal Structure of HasAp with Fe-5,15-bisethynyl-10,20-diphenylporphyrin	Pseudomonas aeruginosa str. PAO1	1.9	X-RAY DIFFRACTION	100.0
6JLG	TRANSPORT PROTEIN	03/05/19	Crystal Structure of HasAp with Co-9,10,19,20-Tetraphenylporphycene	Pseudomonas aeruginosa	2.5	X-RAY DIFFRACTION	100.0
7VM1	TRANSPORT PROTEIN	10/06/21	Crystal Structure of HasAp Capturing Iron Tetra(4-pyridyl)porphyrin	Pseudomonas aeruginosa str. PAO1	2	X-RAY DIFFRACTION	100.0
7VF7	METAL TRANSPORT	09/10/21	Crystal Structure of HasAp with Co-octaethylporphyrin	Pseudomonas aeruginosa str. PAO1	1.35	X-RAY DIFFRACTION	100.0
6U87	METAL BINDING PROTEIN	09/04/19	Pseudomonas aeruginosa HasA mutant - Y75H	Pseudomonas aeruginosa	1.3	X-RAY DIFFRACTION	99.5
7EMR	TRANSPORT PROTEIN	04/14/21	Crystal Structure of HasAp Capturing Cobalt Tetraphenylporphyrin	Pseudomonas aeruginosa str. PAO1	1.55	X-RAY DIFFRACTION	100.0
7VF8	METAL TRANSPORT	09/10/21	Crystal Structure of HasAp with Co-5-octaethyloxaporphyrinium cation	Pseudomonas aeruginosa str. PAO1	1.35	X-RAY DIFFRACTION	100.0
7EMO	TRANSPORT PROTEIN	04/14/21	Crystal Structure of HasAp Capturing Iron Tetraphenylporphyrin	Pseudomonas aeruginosa str. PAO1	1.5	X-RAY DIFFRACTION	100.0
6URB	METAL BINDING PROTEIN	10/23/19	Pseudomonas aeruginosa HasA mutant - H32A	Pseudomonas aeruginosa	2.096	X-RAY DIFFRACTION	99.5

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 6 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002223 (338 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_20020 Search term: hasAp Search term: heme acquisition protein HasAp

Human Homologs

References