Pseudomonas aeruginosa UCBPP-PA14, PA14_21990

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_21990
Name
Replicon	chromosome
Genomic location	1912348 - 1913637 (- strand)
Transposon Mutants	2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	4 transposon mutants in orthologs

Cross-References

RefSeq	YP_789908.1
GI	116051260
Entrez	4381245
INSDC	ABJ12496.1
NCBI Locus Tag	PA14_21990
UniParc	UPI0000396015
UniProtKB Acc	Q02Q78
UniProtKB ID	APEB_PSEAB
UniRef100	UniRef100_Q02Q78
UniRef50	UniRef50_Q87YC5
UniRef90	UniRef90_A6V2H4

Product

Feature Type	CDS
Coding Frame	1
Product Name	aminopeptidase 2
Synonyms
Evidence for Translation
Charge (pH 7)	-9.38
Kyte-Doolittle Hydrophobicity Value	-0.133
Molecular Weight (kDa)	46.6
Isoelectric Point (pI)	5.96

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4OIW	HYDROLASE	01/20/14	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.44	X-RAY DIFFRACTION	99.3
4NJQ	HYDROLASE	11/11/13	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.702	X-RAY DIFFRACTION	99.5
3WT4	HYDROLASE	04/07/14	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.3	X-RAY DIFFRACTION	99.5
4OID	HYDROLASE	01/19/14	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa PAO1	2.3	X-RAY DIFFRACTION	99.3
2IJZ	HYDROLASE	10/02/06	Crystal structure of aminopeptidase	Pseudomonas aeruginosa	3	X-RAY DIFFRACTION	99.3
4NJR	HYDROLASE	11/11/13	Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.3	X-RAY DIFFRACTION	99.5

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 157 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002361 (536 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_21990 Search term: aminopeptidase 2

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000431076 aspartyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:2981] E-value: 1.8e-90 Percent Identity: 41.6
Ensembl 110, assembly GRCh38.p14	ENSP00000273075 aspartyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:2981] E-value: 1.8e-90 Percent Identity: 41.6
Ensembl 110, assembly GRCh38.p14	ENSP00000429468 aspartyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:2981] E-value: 1.8e-90 Percent Identity: 41.6

References