Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
Locus Tag |
PA14_22730
|
Name |
cpxS
|
Replicon | chromosome |
Genomic location | 1976668 - 1978005 (- strand) |
Transposon Mutants | 1 transposon mutants in UCBPP-PA14 |
Transposon Mutants in orthologs | 3 transposon mutants in orthologs |
Comment | Two-component sensor kinase involved in cellular hysteresis response to beta-lactam antibiotics |
RefSeq | YP_789973.1 |
GI | 116051196 |
Entrez | 4381200 |
INSDC | ABJ12432.1 |
NCBI Locus Tag | PA14_22730 |
UniParc | UPI0000395FF0 |
UniProtKB Acc | Q02Q13 |
UniProtKB ID | Q02Q13_PSEAB |
UniRef100 | UniRef100_Q02Q13 |
UniRef50 | UniRef50_Q4KGB6 |
UniRef90 | UniRef90_Q02Q13 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
CpxS
|
Synonyms |
two-component sensor |
Evidence for Translation | |
Charge (pH 7) | 9.87 |
Kyte-Doolittle Hydrophobicity Value | -0.269 |
Molecular Weight (kDa) | 50.3 |
Isoelectric Point (pI) | 10.08 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 620 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002409 (536 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_22730
Search term: cpxS
Search term: CpxS
|
Cellular hysteresis as a principle to maximize the efficacy of antibiotic therapy.
Roemhild R, Gokhale CS, Dirksen P, Blake C, Rosenstiel P, Traulsen A, Andersson DI, Schulenburg H
Proc Natl Acad Sci U S A 2018 Sep 25;115(39):9767-9772
PubMed ID: 30209218
|