Pseudomonas aeruginosa UCBPP-PA14, PA14_22730 (cpxS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_22730
Name
cpxS
Replicon chromosome
Genomic location 1976668 - 1978005 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 3 transposon mutants in orthologs
CommentTwo-component sensor kinase involved in cellular hysteresis response to beta-lactam antibiotics

Cross-References

RefSeq YP_789973.1
GI 116051196
Entrez 4381200
INSDC ABJ12432.1
NCBI Locus Tag PA14_22730
UniParc UPI0000395FF0
UniProtKB Acc Q02Q13
UniProtKB ID Q02Q13_PSEAB
UniRef100 UniRef100_Q02Q13
UniRef50 UniRef50_Q4KGB6
UniRef90 UniRef90_Q02Q13

Product

Feature Type CDS
Coding Frame 1
Product Name
CpxS
Product Name Confidence: Class 1
Synonyms two-component sensor
Evidence for Translation
Charge (pH 7) 9.87
Kyte-Doolittle Hydrophobicity Value -0.269
Molecular Weight (kDa) 50.3
Isoelectric Point (pI) 10.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 620 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002409 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_22730
Search term: cpxS
Search term: CpxS

Human Homologs

References

Cellular hysteresis as a principle to maximize the efficacy of antibiotic therapy.
Roemhild R, Gokhale CS, Dirksen P, Blake C, Rosenstiel P, Traulsen A, Andersson DI, Schulenburg H
Proc Natl Acad Sci U S A 2018 Sep 25;115(39):9767-9772
PubMed ID: 30209218