Pseudomonas aeruginosa UCBPP-PA14, PA14_23590 (sawR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_23590
Name
sawR
Replicon chromosome
Genomic location 2053723 - 2054265 (+ strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentSawR down-regulates the expression levels of hmgA and this causes the accumulation of the brown pigment pyomelanin. Note that SawR does not bind directly to the hmgA promoter.
CommentsawR is highly overexpressed when P. aeruginosa is exposed to Surface Acoustic Waves.

Cross-References

RefSeq YP_790040.1
GI 116051129
Entrez 4381133
INSDC ABJ12365.1
NCBI Locus Tag PA14_23590
UniParc UPI0000395FCF
UniProtKB Acc Q02PU6
UniProtKB ID Q02PU6_PSEAB
UniRef100 UniRef100_W0YVB7
UniRef50 UniRef50_Q9HZ91
UniRef90 UniRef90_Q9HZ91

Product

Feature Type CDS
Coding Frame 1
Product Name
SawR
Product Name Confidence: Class 1
Synonyms transcriptional regulator
Evidence for Translation
Charge (pH 7) -1.31
Kyte-Doolittle Hydrophobicity Value 0.022
Molecular Weight (kDa) 19.1
Isoelectric Point (pI) 6.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2FD5 TRANSCRIPTION REGULATOR 12/13/05 The crystal structure of a transcriptional regulator from Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa 1.7 X-RAY DIFFRACTION 99.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 158 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002465 (448 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_23590
Search term: sawR
Search term: SawR

Human Homologs

References

Surface acoustic waves increase the susceptibility of Pseudomonas aeruginosa biofilms to antibiotic treatment.
Kopel M, Degtyar E, Banin E
Biofouling 2011 Aug;27(7):701-10
PubMed ID: 21732715
SawR a new regulator controlling pyomelanin synthesis in Pseudomonas aeruginosa.
Ben-David Y, Zlotnik E, Zander I, Yerushalmi G, Shoshani S, Banin E
Microbiol Res 2018 Jan;206:91-98
PubMed ID: 29146265