Pseudomonas aeruginosa UCBPP-PA14, PA14_50220 (fleQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_50220
Name
fleQ
Replicon chromosome
Genomic location 4460872 - 4462344 (- strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_792172.1
GI 116049026
Entrez 4380062
INSDC ABJ10262.1
NCBI Locus Tag PA14_50220
UniParc UPI00000D421B
UniProtKB Acc Q02IR4
UniProtKB ID Q02IR4_PSEAB
UniRef100 UniRef100_G3XCV0
UniRef50 UniRef50_G3XCV0
UniRef90 UniRef90_G3XCV0

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator FleQ
Synonyms
Evidence for Translation
Charge (pH 7) -13.91
Kyte-Doolittle Hydrophobicity Value -0.364
Molecular Weight (kDa) 55.3
Isoelectric Point (pI) 5.03

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5EXS TRANSCRIPTION 11/24/15 AAA+ ATPase FleQ from Pseudomonas aeruginosa bound to ATP-gamma-S Pseudomonas aeruginosa 2.5 X-RAY DIFFRACTION 100.0
4WXM TRANSCRIPTION REGULATOR 11/14/14 FleQ REC domain from Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa PAO1 2.3 X-RAY DIFFRACTION 100.0
5EXP TRANSCRIPTION 11/24/15 AAA+ domain of FleQ from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 100.0
6J7E TRANSCRIPTION 01/18/19 Crystal Structure of Central domain of FleQ in complex with ATPgS and Mg Pseudomonas aeruginosa 2.4 X-RAY DIFFRACTION 99.6
6JDL TRANSCRIPTION 02/01/19 Central domain of FleQ H287A mutant in complex with ATPgS and Mg Pseudomonas aeruginosa 2.249 X-RAY DIFFRACTION 99.2
7EJW TRANSCRIPTION 04/02/21 Crystal structure of FleN in complex with FleQ AAA+ doamain Pseudomonas aeruginosa PAO1 1.98 X-RAY DIFFRACTION 99.6
5EXT TRANSCRIPTION 11/24/15 AAA+ domain of FleQ from Pseudomonas aeruginosa bound to ADP Pseudomonas aeruginosa 2.4 X-RAY DIFFRACTION 100.0
6JDI TRANSCRIPTION 02/01/19 Central domain of FleQ H287N mutant in complex with ATPgS and Mg Pseudomonas aeruginosa 1.95 X-RAY DIFFRACTION 99.2
5EXX TRANSCRIPTION 11/24/15 AAA+ ATPase FleQ from Pseudomonas aeruginosa bound to c-di-GMP Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 3.311 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 453 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001058 (532 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_50220
Search term: fleQ

Human Homologs

References

No references are associated with this feature.