Pseudomonas aeruginosa UCBPP-PA14, PA14_70280 (argB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_70280
Name
argB
Replicon chromosome
Genomic location 6266710 - 6267615 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq YP_793797.1
GI 116053470
EC Number 2.7.2.8
Entrez 4384025
INSDC ABJ14706.1
NCBI Locus Tag PA14_70280
UniParc UPI0000165EDF
UniProtKB Acc Q02E39
UniProtKB ID ARGB_PSEAB
UniRef100 UniRef100_B7V5L4
UniRef50 UniRef50_Q4K3S0
UniRef90 UniRef90_Q4K3S0

Product

Feature Type CDS
Coding Frame 1
Product Name
acetylglutamate kinase
Synonyms
Evidence for Translation
Charge (pH 7) -0.59
Kyte-Doolittle Hydrophobicity Value 0.184
Molecular Weight (kDa) 31.8
Isoelectric Point (pI) 6.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2BUF TRANSFERASE 06/12/05 Arginine Feed-Back Inhibitable Acetylglutamate Kinase PSEUDOMONAS AERUGINOSA 2.95 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
N-Acetyl-L-Glutamate DB04075 DrugBank 5.1.4 Q9HTN2 Acetylglutamate kinase 100.0 301 1.8e-164

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 579 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004894 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_70280
Search term: argB

Human Homologs

References

No references are associated with this feature.