Pseudomonas aeruginosa UCBPP-PA14, PA14_43180

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_43180
Name
Replicon	chromosome
Genomic location	3846579 - 3847340 (- strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	14 transposon mutants in orthologs

Cross-References

RefSeq	YP_791601.1
GI	116049594
Entrez	4381802
INSDC	ABJ10830.1
NCBI Locus Tag	PA14_43180
UniParc	UPI00003967DB
UniProtKB Acc	Q02KD5
UniProtKB ID	Q02KD5_PSEAB
UniRef100	UniRef100_S0IYA5
UniRef50	UniRef50_D3P0W3
UniRef90	UniRef90_B7UV72

Product

Feature Type	CDS
Coding Frame	1
Product Name	short chain dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7)	-2.96
Kyte-Doolittle Hydrophobicity Value	0.375
Molecular Weight (kDa)	25.8
Isoelectric Point (pI)	6.02

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown (This protein may have multiple localization sites) Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
7DJS	OXIDOREDUCTASE	11/21/20	Crystal structure of isopiperitenol dehydrogenase from Pseudomonas aeruginosa complexed with NAD	Pseudomonas aeruginosa	1.7	X-RAY DIFFRACTION	98.4

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 652 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000180 (2633 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_43180 Search term: short chain dehydrogenase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000326219 dehydrogenase/reductase 4 [Source:HGNC Symbol;Acc:HGNC:16985] E-value: 1.2e-25 Percent Identity: 33.9
Ensembl 110, assembly GRCh38.p14	ENSP00000518355 dehydrogenase/reductase 4 [Source:HGNC Symbol;Acc:HGNC:16985] E-value: 1.2e-25 Percent Identity: 33.9

References