Pseudomonas aeruginosa PAK, PAK_05273 (pmrA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAK - Assembly GCF_000408865.1
GCF_000408865.1|latest |
| Locus Tag |
PAK_05273
|
| Name |
pmrA
|
| Replicon | chromosome |
| Genomic location | 5726751 - 5727416 (+ strand) |
Cross-References
| RefSeq | WP_003095244.1 |
| GI | 489185824 |
| NCBI Locus Tag | PAK_05273 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
two-component regulator system response regulator PmrA
|
| Synonyms |
transcriptional regulator |
| Evidence for Translation | |
| Charge (pH 7) | -3.56 |
| Kyte-Doolittle Hydrophobicity Value | -0.191 |
| Molecular Weight (kDa) | 24.4 |
| Isoelectric Point (pI) | 5.96 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| basR | Response regulator for Lipid A modification genes; two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). [PMID:25006521] | ARO:3003582 | protein variant model | L71R | Strict | 432.2 | 99.55 | 3.2.5 |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG004418 (471 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PAK_05273
Search term: pmrA
|
Human Homologs
References
|
PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A.
Moskowitz SM, Ernst RK, Miller SI
J Bacteriol 2004 Jan;186(2):575-9
PubMed ID: 14702327
|