Pseudomonas aeruginosa PAO1, PA1954 (fapC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1954
Name
fapC
Replicon chromosome
Genomic location 2139354 - 2140376 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250644.1
GI 15597150
Affymetrix PA1954_at
Entrez 880832
GenBank AAG05342.1
INSDC AAG05342.1
NCBI Locus Tag PA1954
protein_id(GenBank) gb|AAG05342.1|AE004622_4|gnl|PseudoCAP|PA1954
TIGR NTL03PA01954
UniParc UPI00000C552A
UniProtKB Acc Q9I2F0
UniProtKB ID Q9I2F0_PSEAE
UniRef100 UniRef100_W0YSR7
UniRef50 UniRef50_Q02LA0
UniRef90 UniRef90_Q02LA0

Product

Feature Type CDS
Coding Frame 1
Product Name
FapC
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -5.12
Kyte-Doolittle Hydrophobicity Value -0.274
Molecular Weight (kDa) 33.9
Isoelectric Point (pI) 4.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 11 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003478 (463 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1954
Search term: fapC
Search term: FapC

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Functional amyloid in Pseudomonas.
Dueholm MS, Petersen SV, Sønderkær M, Larsen P, Christiansen G, Hein KL, Enghild JJ, Nielsen JL, Nielsen KL, Nielsen PH, Otzen DE
Mol Microbiol 2010 Aug;77(4):1009-20
PubMed ID: 20572935
Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation.
Dueholm MS, Søndergaard MT, Nilsson M, Christiansen G, Stensballe A, Overgaard MT, Givskov M, Tolker-Nielsen T, Otzen DE, Nielsen PH
Microbiologyopen 2013 Jun;2(3):365-82
PubMed ID: 23504942