Pseudomonas aeruginosa PAO1, PA3947 (rocR)

Annotation Updates

Date	Description	Acknowledgements
Jan 24, 2007	New gene name: rocR (Existing value: blank). New product name: RocR (Existing value: probable two-component response regulator). New evidence reference (PMID): 15659157. New product name confidence: Class 1 (Existing value: Class 3). Deleting structue feature: PF00563: Domain of unknown function 2. New structure feature: PF00563: EAL domain (characteristic of phosphodiesterases). New comment: Overexpression of PA3947 impairs TTSS-mediated cytotoxicity. New evidence reference (PMID): 16477007. New PseudoCAP function class: Nucleotide biosynthesis and metabolism.	Hemantha Kulasekara, Department of Microbiology and Molecular Genetics, Harvard Medical School, USA.
Nov 24, 2014	New PubMed ID: 16477007.	Literature review. Geoffrey L. Winsor (Brinkman Lab). Simon Fraser University, Canada
Aug 25, 2011	New comment : RocR has been shown to have c-di-GMP phosphodiesterase activity and to repress the expression of the cupB and cupC gene clusters.. New comment : Genetic and bacterial two hybrid studies in Pseudomonas aeruginosa PAK have revealed that RocS1-induced expression of the cupB and cupC gene clusters is repressed by RocR. Furthermore, purified RocR has been shown to display phosphodiesterase activity and degrades the second messenger c-di-GMP.. New PubMed reference: 18344366. New PubMed reference: 21205015.	Allain Filloux, Imperial College London