Pseudomonas aeruginosa PAO1, PA3948 (rocA1)

Annotation Updates

Date	Description	Acknowledgements
Jan 24, 2007	New product name confidence: Class 1 (Existing value: Class 3). New product name: two-component response regulator RocA1 (Existing value: probable two-component response regulator). New gene name: rocA1 (Existing value: blank). New evidence reference (PMID): 15659157.	Literature review. Approved by reference author Hemantha Kulasekara, Department of Microbiology and Molecular Genetics, Harvard Medical School, USA.
Aug 25, 2011	New product name: Two-component response regulator RocA1. New comment : RocA1 can interact with two sensors, RocS1 (PA3946) and RocS2 (PA3044) and activates transcription of the cupC gene cluster.. New comment : Functional studies in Pseudomonas aeruginosa PAK have shown that overexpression of RocA1 activates transcription of the cupC gene cluster, which leads to the production and assembly of CupC fimbriae on the cell surface and increases biofilm formation. Genetic and bacterial two hybrid analyses have shown that RocA1 can be activated by the RocS1 sensor, as well as the paralogous RocS2 sensor (PA3044).. New PubMed reference: 15659157. New PubMed reference: 21205015.	Allain Filloux, Imperial College London
Apr 29, 2002	Subcellular localization information added based on significance similarity to protein of known localization. Localization: Cytoplasmic. Localization Rating: Class 2.	Jennifer L. Gardy & Fiona Brinkman, Simon Fraser University, Canada