Pseudomonas aeruginosa PAO1, PA5164 (rmlC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity
EXP
Inferred from Experiment 		ECO:0000269
experimental evidence used in manual assertion		 17046787 Reviewed by curator
Molecular Function GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 10455186 Reviewed by curator
Cellular Component GO:0009276 Gram-negative-bacterium-type cell wall
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0019305 dTDP-rhamnose biosynthetic process
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 17046787 Reviewed by curator
Biological Process GO:0009244 lipopolysaccharide core region biosynthetic process
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 11065359 Reviewed by curator
Biological Process GO:0009243 O antigen biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 9023210 Reviewed by curator
Biological Process GO:0019305 dTDP-rhamnose biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 10455186 Reviewed by curator
Molecular Function GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00438
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc DTDPRHAMSYN-PWY dTDP-L-rhamnose biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc OANTIGEN-PWY O-antigen building blocks biosynthesis (E. coli) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00523 Polyketide sugar unit biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00521 Streptomycin biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF51182 RmlC-like cupins IPR011051 RmlC-like cupin domain superfamily 1 178 8.22E-80
NCBIfam TIGR01221 JCVI: dTDP-4-dehydrorhamnose 3,5-epimerase IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-like 3 177 5.4E-90
Gene3D G3DSA:2.60.120.10 Jelly Rolls IPR014710 RmlC-like jelly roll fold 1 181 6.8E-80
Pfam PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-like 6 175 3.7E-75
CDD cd00438 cupin_RmlC IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-like 3 170 1.16535E-106
PANTHER PTHR21047 DTDP-6-DEOXY-D-GLUCOSE-3,5 EPIMERASE IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-like 2 176 1.1E-71
FunFam G3DSA:2.60.120.10:FF:000051 dTDP-4-dehydrorhamnose 3,5-epimerase - - 1 181 8.0E-95

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.