Pseudomonas aeruginosa UCBPP-PA14, PA14_18580 (algD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0051287 NAD binding
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA3540
 ECO:0000249
sequence similarity evidence used in automatic assertion		 12705829
Molecular Function GO:0047919 GDP-mannose 6-dehydrogenase activity
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA3540
 ECO:0000249
sequence similarity evidence used in automatic assertion		 7521247
Biological Process GO:0042121 alginic acid biosynthetic process
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA3540
 ECO:0000249
sequence similarity evidence used in automatic assertion		 7521247
Biological Process GO:0042710 biofilm formation
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA3540
 ECO:0000249
sequence similarity evidence used in automatic assertion		 7521247
Biological Process GO:0042121 alginic acid biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF500135
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00984
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR03026
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0047919 GDP-mannose 6-dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF500135
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other UCBPP-PA14 genes in this class
Adaptation, Protection Other UCBPP-PA14 genes in this class
Secreted Factors (toxins, enzymes, alginate) Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau00520 Amino sugar and nucleotide sugar metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau02020 Two-component system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00051 Fructose and mannose metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation 205 298 2.1E-28
Gene3D G3DSA:3.40.50.720 - - - 1 202 5.9E-80
SUPERFAMILY SSF52413 UDP-glucose/GDP-mannose dehydrogenase C-terminal domain IPR036220 UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily 305 434 2.62E-25
Gene3D G3DSA:1.20.5.170 - - - 203 234 6.4E-20
Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal 318 405 2.6E-12
NCBIfam TIGR03026 JCVI: nucleotide sugar dehydrogenase IPR017476 UDP-glucose/GDP-mannose dehydrogenase 1 410 1.1E-130
PIRSF PIRSF500135 GDPman_DH IPR028358 GDP-mannose 6-dehydrogenase 1 436 0.0
Gene3D G3DSA:3.40.50.720 - - - 235 436 3.3E-58
SMART SM00984 UDPG_MGDP_dh_C_a_2_a IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal 317 425 2.2E-19
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 204 300 7.48E-28
PIRSF PIRSF000124 UDPglc_GDPman_dh IPR017476 UDP-glucose/GDP-mannose dehydrogenase 1 436 0.0
FunFam G3DSA:3.40.50.720:FF:000573 GDP-mannose 6-dehydrogenase - - 1 202 0.0
Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal 1 190 6.0E-63
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 1 195 2.91E-51
FunFam G3DSA:3.40.50.720:FF:000664 GDP-mannose 6-dehydrogenase - - 235 436 0.0
PANTHER PTHR43750 UDP-GLUCOSE 6-DEHYDROGENASE TUAD - - 1 404 3.1E-114

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.