Pseudomonas aeruginosa PAO1, PA0105 (coxB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0105
Name
coxB
Synonym: coII
Replicon chromosome
Genomic location 127378 - 128502 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_248795.1
GI 15595303
Affymetrix PA0105_coxB_at
Entrez 881940
GenBank AAG03495.1
INSDC AAG03495.1
NCBI Locus Tag PA0105
protein_id(GenBank) gb|AAG03495.1|AE004449_4|gnl|PseudoCAP|PA0105
TIGR NTL03PA00106
UniParc UPI00000C4F3A
UniProtKB Acc Q9I727
UniProtKB ID Q9I727_PSEAE
UniRef100 UniRef100_Q9I727
UniRef50 UniRef50_Q4KKM0
UniRef90 UniRef90_Q9I727

Product

Feature Type CDS
Coding Frame 1
Product Name
cytochrome c oxidase, subunit II
Product Name Confidence: Class 2
Evidence for Translation
Charge (pH 7) -3.78
Kyte-Doolittle Hydrophobicity Value -0.092
Molecular Weight (kDa) 42.2
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 416 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000103 (519 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0105
Search term: coxB

Human Homologs

Ensembl 86, assembly GRCh38.p7
mitochondrially encoded cytochrome c oxidase II [Source:HGNC Symbol;Acc:HGNC:7421]
E-value: 4.0e-33
Percent Identity: 32.3

Transposon Insertions in PAO1

Type ISphoA/hah insertion site
Mutant ID UWGC: 32580
Genomic Position 128182
Position in ORF 805(1125)
Reference 14617778
Type ISphoA/hah insertion site
Mutant ID UWGC: 31535
Genomic Position 127864
Position in ORF 487(1125)
Reference 14617778

Transposon Insertions in Orthologs

References

Structure at 2.8 A resolution of cytochrome c oxidase from Paracoccus denitrificans.
Iwata S, Ostermeier C, Ludwig B, Michel H
Nature 1995 Aug;376(6542):660-9
PubMed ID: 7651515
Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment.
Ostermeier C, Harrenga A, Ermler U, Michel H
Proc. Natl. Acad. Sci. U.S.A. 1997 Sep;94(20):10547-53
PubMed ID: 9380672