Pseudomonas aeruginosa PAO1, PA0230 (pcaB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0230
Name
pcaB
Replicon chromosome
Genomic location 259784 - 261163 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_248921.1
GI 15595427
Affymetrix PA0230_pcaB_at
Entrez 881957
GenBank AAG03619.1
INSDC AAG03619.1
NCBI Locus Tag PA0230
protein_id(GenBank) gb|AAG03619.1|AE004461_2|gnl|PseudoCAP|PA0230
TIGR NTL03PA00231
UniParc UPI00000C4FAD
UniProtKB Acc Q9I6Q8
UniProtKB ID PCAB_PSEAE
UniRef100 UniRef100_Q9I6Q8
UniRef50 UniRef50_P32427
UniRef90 UniRef90_Q9I6Q8

Product

Feature Type CDS
Coding Frame 1
Product Name
3-carboxy-cis,cis-muconate cycloisomerase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -6.52
Kyte-Doolittle Hydrophobicity Value 0.039
Molecular Weight (kDa) 49.1
Isoelectric Point (pI) 6.24

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 634 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000229 (504 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0230
Search term: pcaB

Human Homologs

References

3-Carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida is homologous to the class II fumarase family: a new reaction in the evolution of a mechanistic motif.
Williams SE, Woolridge EM, Ransom SC, Landro JA, Babbitt PC, Kozarich JW
Biochemistry 1992 Oct 13;31(40):9768-76
PubMed ID: 1390752