Pseudomonas aeruginosa UCBPP-PA14, PA14_18580 (algD)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_18580
Name	algD
Replicon	chromosome
Genomic location	1593998 - 1595308 (- strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	YP_789625.1
GI	116051539
Entrez	4381505
INSDC	ABJ12775.1
NCBI Locus Tag	PA14_18580
UniParc	UPI000012584C
UniProtKB Acc	Q02R11
UniProtKB ID	Q02R11_PSEAB
UniRef100	UniRef100_P11759
UniRef50	UniRef50_P11759
UniRef90	UniRef90_P11759

Product

Feature Type	CDS
Coding Frame	1
Product Name	GDP-mannose 6-dehydrogenase AlgD
Synonyms
Evidence for Translation
Charge (pH 7)	-9.09
Kyte-Doolittle Hydrophobicity Value	-0.051
Molecular Weight (kDa)	47.6
Isoelectric Point (pI)	5.35

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
1MUU	OXIDOREDUCTASE	09/24/02	2.0 A crystal structure of GDP-mannose dehydrogenase	Pseudomonas aeruginosa	2.02	X-RAY DIFFRACTION	100.0
1MV8	OXIDOREDUCTASE	09/24/02	1.55 A crystal structure of a ternary complex of GDP-mannose dehydrogenase from Psuedomonas aeruginosa	Pseudomonas aeruginosa	1.55	X-RAY DIFFRACTION	100.0
1MFZ	OXIDOREDUCTASE	08/14/02	Partially refined 2.8 A Crystal structure of GDP-mannose dehydrogenase from P. aeruginosa	Pseudomonas aeruginosa	2.8	X-RAY DIFFRACTION	100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name	Source Accession	Source DB	Version	Target Accession	Target Description	Percent Identity	Alignment Length	E-Value
Guanosine 5'-(Trihydrogen Diphosphate), P'-D-Mannopyranosyl Ester	DB04023	DrugBank	5.1.4	P11759	GDP-mannose 6-dehydrogenase	100.0	436	7.2e-252
Sucrose	DB02772	DrugBank	5.1.4	P11759	GDP-mannose 6-dehydrogenase	100.0	436	7.2e-252

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 588 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002126 (490 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_18580 Search term: algD Search term: GDP-mannose 6-dehydrogenase AlgD

Human Homologs

References