Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2524
|
Name |
czcS
|
Replicon | chromosome |
Genomic location | 2844489 - 2845907 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | This two-component system is involved in cadmiun, zinc and cobalt resistance with homology to the CzcRS of Cupriavidus metallidurans. |
RefSeq | NP_251214.1 |
GI | 15597720 |
Affymetrix | PA2524_at |
Entrez | 878718 |
GenBank | AAG05912.1 |
INSDC | AAG05912.1 |
NCBI Locus Tag | PA2524 |
protein_id(GenBank) | gb|AAG05912.1|AE004679_6|gnl|PseudoCAP|PA2524 |
TIGR | NTL03PA02524 |
UniParc | UPI00000C571C |
UniProtKB Acc | Q9I0V9 |
UniProtKB ID | Q9I0V9_PSEAE |
UniRef100 | UniRef100_Q9I0V9 |
UniRef50 | UniRef50_Q02MX2 |
UniRef90 | UniRef90_Q02MX2 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
CzcS
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | 0.57 |
Kyte-Doolittle Hydrophobicity Value | -0.155 |
Molecular Weight (kDa) | 51.9 |
Isoelectric Point (pI) | 7.09 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
5GPO | TRANSFERASE | 08/03/16 | The sensor domain structure of the zinc-responsive histidine kinase CzcS from Pseudomonas Aeruginosa | Pseudomonas aeruginosa | 1.701 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 618 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003042 (473 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2524
Search term: czcS
Search term: CzcS
|
CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa.
Perron K, Caille O, Rossier C, Van Delden C, Dumas JL, Köhler T
J Biol Chem 2004 Mar 5;279(10):8761-8
PubMed ID: 14679195
|
The transcriptional regulator CzcR modulates antibiotic resistance and quorum sensing in Pseudomonas aeruginosa.
Dieppois G, Ducret V, Caille O, Perron K
PLoS One 2012;7(5):e38148
PubMed ID: 22666466
|
A copper-activated two-component system interacts with zinc and imipenem resistance in Pseudomonas aeruginosa.
Caille O, Rossier C, Perron K
J Bacteriol 2007 Jul;189(13):4561-8
PubMed ID: 17449606
|