Pseudomonas aeruginosa PAO1, PA3339 (plpD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3339
Name
plpD
Synonym: PlpD
Replicon chromosome
Genomic location 3747525 - 3749711 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252029.1
GI 15598535
Affymetrix PA3339_at
Entrez 882504
GenBank AAG06727.1
INSDC AAG06727.1
NCBI Locus Tag PA3339
protein_id(GenBank) gb|AAG06727.1|AE004756_5|gnl|PseudoCAP|PA3339
TIGR NTL03PA03339
UniParc UPI00000C59C1
UniProtKB Acc Q9HYQ6
UniProtKB ID Q9HYQ6_PSEAE
UniRef100 UniRef100_Q9HYQ6
UniRef50 UniRef50_Q4KGC6
UniRef90 UniRef90_Q9HYQ6

Product

Feature Type CDS
Coding Frame 1
Product Name
patatin-like protein, PlpD
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -11.28
Kyte-Doolittle Hydrophobicity Value -0.245
Molecular Weight (kDa) 80.9
Isoelectric Point (pI) 5.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
Outer Membrane Class 3
Outer Membrane Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5FQU TRANSPORT PROTEIN 12/14/15 Orthorhombic crystal structure of of PlpD (selenomethionine derivative) PSEUDOMONAS AERUGINOSA PAO1 2.74 X-RAY DIFFRACTION 100.0
5FYA HYDROLASE 03/04/16 Cubic crystal of the native PlpD PSEUDOMONAS AERUGINOSA 2.141 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 387 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002289 (484 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3339
Search term: plpD

Human Homologs

Ensembl 110, assembly GRCh38.p14
patatin like phospholipase domain containing 6 [Source:HGNC Symbol;Acc:HGNC:16268]
E-value: 3.4e-25
Percent Identity: 29.6
Ensembl 110, assembly GRCh38.p14
patatin like phospholipase domain containing 6 [Source:HGNC Symbol;Acc:HGNC:16268]
E-value: 3.4e-25
Percent Identity: 29.6
Ensembl 110, assembly GRCh38.p14
patatin like phospholipase domain containing 6 [Source:HGNC Symbol;Acc:HGNC:16268]
E-value: 3.4e-25
Percent Identity: 29.6
Ensembl 110, assembly GRCh38.p14
patatin like phospholipase domain containing 6 [Source:HGNC Symbol;Acc:HGNC:16268]
E-value: 3.4e-25
Percent Identity: 29.6
Ensembl 110, assembly GRCh38.p14
patatin like phospholipase domain containing 6 [Source:HGNC Symbol;Acc:HGNC:16268]
E-value: 3.4e-25
Percent Identity: 29.6

References

The Pseudomonas aeruginosa patatin-like protein PlpD is the archetype of a novel Type V secretion system.
Salacha R, Kovacić F, Brochier-Armanet C, Wilhelm S, Tommassen J, Filloux A, Voulhoux R, Bleves S
Environ. Microbiol. 2010 Jun;12(6):1498-512
PubMed ID: 20192961
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994