Pseudomonas aeruginosa PAO1, PA3415

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3415
Name
Replicon chromosome
Genomic location 3821385 - 3822497 (- strand)
Transposon Mutants 3 transposon mutants in PAO1

Cross-References

RefSeq NP_252105.1
GI 15598611
Affymetrix PA3415_at
Entrez 878691
GenBank AAG06803.1
INSDC AAG06803.1
NCBI Locus Tag PA3415
protein_id(GenBank) gb|AAG06803.1|AE004762_9|gnl|PseudoCAP|PA3415
TIGR NTL03PA03415
UniParc UPI00000C59FD
UniProtKB Acc Q9HYJ0
UniProtKB ID Q9HYJ0_PSEAE
UniRef100 UniRef100_Q9HYJ0
UniRef50 UniRef50_Q0JZ07
UniRef90 UniRef90_A0A022NPE8

Product

Feature Type CDS
Coding Frame 1
Product Name
probable dihydrolipoamide acetyltransferase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.84
Kyte-Doolittle Hydrophobicity Value -0.081
Molecular Weight (kDa) 39.5
Isoelectric Point (pI) 5.47

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 513 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002215 (329 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3415

Human Homologs

Ensembl 110, assembly GRCh38.p14
dihydrolipoamide branched chain transacylase E2 [Source:HGNC Symbol;Acc:HGNC:2698]
E-value: 5.9e-34
Percent Identity: 28.9

References

Three-dimensional structure of the lipoyl domain from Bacillus stearothermophilus pyruvate dehydrogenase multienzyme complex.
Dardel F, Davis AL, Laue ED, Perham RN
J Mol Biol 1993 Feb 20;229(4):1037-48
PubMed ID: 8445635