Pseudomonas aeruginosa PAO1, PA3438 (folE1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3438
Name
folE1
Replicon chromosome
Genomic location 3845775 - 3846335 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252128.1
GI 15598634
Affymetrix PA3438_folE1_at
Entrez 878765
GenBank AAG06826.1
INSDC AAG06826.1
NCBI Locus Tag PA3438
protein_id(GenBank) gb|AAG06826.1|AE004764_12|gnl|PseudoCAP|PA3438
TIGR NTL03PA03438
UniParc UPI000012B276
UniProtKB Acc Q9HYG8
UniProtKB ID GCH11_PSEAE
UniRef100 UniRef100_Q9HYG8
UniRef50 UniRef50_Q15YG1
UniRef90 UniRef90_Q9HYG8

Product

Feature Type CDS
Coding Frame 1
Product Name
GTP cyclohydrolase I precursor
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 1.34
Kyte-Doolittle Hydrophobicity Value -0.083
Molecular Weight (kDa) 20.8
Isoelectric Point (pI) 7.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 471 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002198 (478 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3438
Search term: folE1

Human Homologs

Ensembl 110, assembly GRCh38.p14
GTP cyclohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:4193]
E-value: 8.6e-58
Percent Identity: 57.8
Ensembl 110, assembly GRCh38.p14
GTP cyclohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:4193]
E-value: 8.6e-58
Percent Identity: 57.8

References

Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway.
Hatakeyama K, Inoue Y, Harada T, Kagamiyama H
J Biol Chem 1991 Jan 15;266(2):765-9
PubMed ID: 1985963
Biosynthesis of tetrahydrofolate. Sequence of GTP cyclohydrolase I from Escherichia coli.
Katzenmeier G, Schmid C, Kellermann J, Lottspeich F, Bacher A
Biol Chem Hoppe Seyler 1991 Nov;372(11):991-7
PubMed ID: 1665332