Pseudomonas aeruginosa PAO1, PA1254 (lhpC)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA1254
Name	lhpC
Replicon	chromosome
Genomic location	1362371 - 1363288 (- strand)
Transposon Mutants	1 transposon mutants in PAO1
Transposon Mutants in orthologs	5 transposon mutants in orthologs

Cross-References

RefSeq	NP_249945.1
GI	15596451
Affymetrix	PA1254_at
DNASU	PaCD00006579
Entrez	881320
GenBank	AAG04643.1
INSDC	AAG04643.1
NCBI Locus Tag	PA1254
protein_id(GenBank)	gb|AAG04643.1|AE004555_3|gnl|PseudoCAP|PA1254
TIGR	NTL03PA01255
UniParc	UPI00000C52D0
UniProtKB Acc	Q9I490
UniProtKB ID	Q9I490_PSEAE
UniRef100	UniRef100_A0A0C7D604
UniRef50	UniRef50_U1LTR1
UniRef90	UniRef90_A0A022NV25

Product

Feature Type	CDS
Coding Frame	1
Product Name	delta1-pyrroline-4-hydroxy-2-carboxylate deaminase, LphC Product Name Confidence: Class 1
Synonyms	probable dihydrodipicolinate synthetase
Evidence for Translation
Charge (pH 7)	-5.73
Kyte-Doolittle Hydrophobicity Value	0.107
Molecular Weight (kDa)	32.9
Isoelectric Point (pI)	5.41

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 632 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000222 (1144 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA1254 Search term: lhpC Search term: delta1-pyrroline-4-hydroxy-2-carboxylate deaminase, LphC

Human Homologs

References

Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1. Li G, Lu CD Microbiology (Reading) 2016 Jul;162(7):1232-1242 PubMed ID: 27145750

Alpha-ketoglutaric semialdehyde dehydrogenase of Pseudomonas. Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes. Adams E, Rosso G J Biol Chem 1967 Apr 25;242(8):1802-14 PubMed ID: 6024771

Identification and characterization of D-hydroxyproline dehydrogenase and Delta1-pyrroline-4-hydroxy-2-carboxylate deaminase involved in novel L-hydroxyproline metabolism of bacteria: metabolic convergent evolution. Watanabe S, Morimoto D, Fukumori F, Shinomiya H, Nishiwaki H, Kawano-Kawada M, Sasai Y, Tozawa Y, Watanabe Y J Biol Chem 2012 Sep 21;287(39):32674-88 PubMed ID: 22833679