Pseudomonas aeruginosa PAO1, PA1254 (lhpC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1254
Name
lhpC
Replicon chromosome
Genomic location 1362371 - 1363288 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq NP_249945.1
GI 15596451
Affymetrix PA1254_at
DNASU PaCD00006579
Entrez 881320
GenBank AAG04643.1
INSDC AAG04643.1
NCBI Locus Tag PA1254
protein_id(GenBank) gb|AAG04643.1|AE004555_3|gnl|PseudoCAP|PA1254
TIGR NTL03PA01255
UniParc UPI00000C52D0
UniProtKB Acc Q9I490
UniProtKB ID Q9I490_PSEAE
UniRef100 UniRef100_A0A0C7D604
UniRef50 UniRef50_U1LTR1
UniRef90 UniRef90_A0A022NV25

Product

Feature Type CDS
Coding Frame 1
Product Name
delta1-pyrroline-4-hydroxy-2-carboxylate deaminase, LphC
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -5.73
Kyte-Doolittle Hydrophobicity Value 0.107
Molecular Weight (kDa) 32.9
Isoelectric Point (pI) 5.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 632 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000222 (1179 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1254
Search term: lhpC

References

Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G, Lu CD
Microbiology (Reading, Engl.) 2016 Jul;162(7):1232-42
PubMed ID: 27145750
Alpha-ketoglutaric semialdehyde dehydrogenase of Pseudomonas. Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes.
Adams E, Rosso G
J. Biol. Chem. 1967 Apr;242(8):1802-14
PubMed ID: 6024771
Identification and characterization of D-hydroxyproline dehydrogenase and Delta1-pyrroline-4-hydroxy-2-carboxylate deaminase involved in novel L-hydroxyproline metabolism of bacteria: metabolic convergent evolution.
Watanabe S, Morimoto D, Fukumori F, Shinomiya H, Nishiwaki H, Kawano-Kawada M, Sasai Y, Tozawa Y, Watanabe Y
J. Biol. Chem. 2012 Sep;287(39):32674-88
PubMed ID: 22833679