Pseudomonas aeruginosa PAO1, PA2227 (vqsM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2227
Name
vqsM
Replicon chromosome
Genomic location 2448568 - 2449545 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
CommentVqsM is a global regulator essential for quorum sensing and virulence modulation

Cross-References

RefSeq NP_250917.1
GI 15597423
Affymetrix PA2227_at
DNASU PaCD00006992
Entrez 882297
GenBank AAG05615.1
INSDC AAG05615.1
NCBI Locus Tag PA2227
protein_id(GenBank) gb|AAG05615.1|AE004649_6|gnl|PseudoCAP|PA2227
TIGR NTL03PA02227
UniParc UPI00000C5619
UniProtKB Acc Q9I1P2
UniProtKB ID VQSM_PSEAE
UniRef100 UniRef100_Q9I1P2
UniRef50 UniRef50_Q9I1P2
UniRef90 UniRef90_Q9I1P2

Product

Feature Type CDS
Coding Frame 1
Product Name
AraC-type transcriptional regulator VqsM
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -0.90
Kyte-Doolittle Hydrophobicity Value -0.214
Molecular Weight (kDa) 37.0
Isoelectric Point (pI) 6.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 169 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG008399 (79 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2227
Search term: vqsM

Human Homologs

References

VqsM, a novel AraC-type global regulator of quorum-sensing signalling and virulence in Pseudomonas aeruginosa.
Dong YH, Zhang XF, Xu JL, Tan AT, Zhang LH
Mol Microbiol 2005 Oct;58(2):552-64
PubMed ID: 16194239