Pseudomonas aeruginosa PAO1, PA2523 (czcR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2523
Name
czcR
Replicon chromosome
Genomic location 2843818 - 2844492 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentThis two-component system is involved in cadmiun, zinc and cobalt resistance with homology to the CzcRS of Cupriavidus metallidurans.

Cross-References

RefSeq NP_251213.1
GI 15597719
Affymetrix PA2523_at
Entrez 882895
GenBank AAG05911.1
INSDC AAG05911.1
NCBI Locus Tag PA2523
protein_id(GenBank) gb|AAG05911.1|AE004679_5|gnl|PseudoCAP|PA2523
TIGR NTL03PA02523
UniParc UPI00000D4245
UniProtKB Acc G3XD16
UniProtKB ID G3XD16_PSEAE
UniRef100 UniRef100_W0YQE9
UniRef50 UniRef50_Q47456
UniRef90 UniRef90_W0YQE9

Product

Feature Type CDS
Coding Frame 1
Product Name
CzcR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.89
Kyte-Doolittle Hydrophobicity Value -0.165
Molecular Weight (kDa) 25.8
Isoelectric Point (pI) 7.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes
Infection model C. elegans killing assay.
Reference 22666466

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 623 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003043 (473 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2523
Search term: czcR
Search term: CzcR

Human Homologs

References

CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa.
Perron K, Caille O, Rossier C, Van Delden C, Dumas JL, Köhler T
J Biol Chem 2004 Mar 5;279(10):8761-8
PubMed ID: 14679195
The transcriptional regulator CzcR modulates antibiotic resistance and quorum sensing in Pseudomonas aeruginosa.
Dieppois G, Ducret V, Caille O, Perron K
PLoS One 2012;7(5):e38148
PubMed ID: 22666466
A copper-activated two-component system interacts with zinc and imipenem resistance in Pseudomonas aeruginosa.
Caille O, Rossier C, Perron K
J Bacteriol 2007 Jul;189(13):4561-8
PubMed ID: 17449606