Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2523
|
Name |
czcR
|
Replicon | chromosome |
Genomic location | 2843818 - 2844492 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | This two-component system is involved in cadmiun, zinc and cobalt resistance with homology to the CzcRS of Cupriavidus metallidurans. |
RefSeq | NP_251213.1 |
GI | 15597719 |
Affymetrix | PA2523_at |
Entrez | 882895 |
GenBank | AAG05911.1 |
INSDC | AAG05911.1 |
NCBI Locus Tag | PA2523 |
protein_id(GenBank) | gb|AAG05911.1|AE004679_5|gnl|PseudoCAP|PA2523 |
TIGR | NTL03PA02523 |
UniParc | UPI00000D4245 |
UniProtKB Acc | G3XD16 |
UniProtKB ID | G3XD16_PSEAE |
UniRef100 | UniRef100_W0YQE9 |
UniRef50 | UniRef50_Q47456 |
UniRef90 | UniRef90_W0YQE9 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
CzcR
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | 1.89 |
Kyte-Doolittle Hydrophobicity Value | -0.165 |
Molecular Weight (kDa) | 25.8 |
Isoelectric Point (pI) | 7.84 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | Caenorhabditis elegans |
Notes | |
Infection model | C. elegans killing assay. |
Reference | 22666466 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 623 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003043 (473 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2523
Search term: czcR
Search term: CzcR
|
CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa.
Perron K, Caille O, Rossier C, Van Delden C, Dumas JL, Köhler T
J Biol Chem 2004 Mar 5;279(10):8761-8
PubMed ID: 14679195
|
The transcriptional regulator CzcR modulates antibiotic resistance and quorum sensing in Pseudomonas aeruginosa.
Dieppois G, Ducret V, Caille O, Perron K
PLoS One 2012;7(5):e38148
PubMed ID: 22666466
|
A copper-activated two-component system interacts with zinc and imipenem resistance in Pseudomonas aeruginosa.
Caille O, Rossier C, Perron K
J Bacteriol 2007 Jul;189(13):4561-8
PubMed ID: 17449606
|