Pseudomonas aeruginosa PAO1, PA2818 (arr)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2818
Name
arr
Replicon chromosome
Genomic location 3171598 - 3173175 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
CommentEAL motifs found in PAO1 and PACS2, but not PA14
CommentOverexpression of PA2818 increaes pellicle formation.

Cross-References

RefSeq NP_251508.1
GI 15598014
Affymetrix PA2818_at
Entrez 878909
GenBank AAG06206.1
INSDC AAG06206.1
NCBI Locus Tag PA2818
protein_id(GenBank) gb|AAG06206.1|AE004708_12|gnl|PseudoCAP|PA2818
TIGR NTL03PA02818
UniParc UPI00000C5824
UniProtKB Acc Q9I025
UniProtKB ID Q9I025_PSEAE
UniRef100 UniRef100_Q9I025
UniRef50 UniRef50_Q9I025
UniRef90 UniRef90_Q9I025

Product

Feature Type CDS
Coding Frame 1
Product Name
aminoglycoside response regulator
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 0.47
Kyte-Doolittle Hydrophobicity Value 0.005
Molecular Weight (kDa) 57.4
Isoelectric Point (pI) 7.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 404 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005131 (64 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2818
Search term: arr

Human Homologs

References

Aminoglycoside antibiotics induce bacterial biofilm formation.
Hoffman LR, D'Argenio DA, MacCoss MJ, Zhang Z, Jones RA, Miller SI
Nature 2005 Aug 25;436(7054):1171-5
PubMed ID: 16121184
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295