Pseudomonas aeruginosa PAO1, PA4503 (dppB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA4503
Name
dppB
Replicon chromosome
Genomic location 5042068 - 5043078 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253193.1
GI 15599699
Affymetrix PA4503_at
Entrez 881080
GenBank AAG07891.1
INSDC AAG07891.1
NCBI Locus Tag PA4503
protein_id(GenBank) gb|AAG07891.1|AE004864_3|gnl|PseudoCAP|PA4503
TIGR NTL03PA04504
UniParc UPI00000C5D3F
UniProtKB Acc Q9HVR8
UniProtKB ID Q9HVR8_PSEAE
UniRef100 UniRef100_A0A031CP50
UniRef50 UniRef50_B2T6W9
UniRef90 UniRef90_M4XC77

Product

Feature Type CDS
Coding Frame 1
Product Name
dipeptide ABC transporter permease DppB
Product Name Confidence: Class 1
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected using LC-MS/MS (36.97 kDa, PMID:21751344)
Charge (pH 7) 2.68
Kyte-Doolittle Hydrophobicity Value 0.656
Molecular Weight (kDa) 37.0
Isoelectric Point (pI) 8.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Outer Membrane Vesicle Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 582 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004090 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4503
Search term: dppB

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.
Pletzer D, Lafon C, Braun Y, Köhler T, Page MG, Mourez M, Weingart H
PLoS ONE 2014 ;9(10):e111311
PubMed ID: 25338022