Pseudomonas aeruginosa PAO1, PA4503 (dppB)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 5042068 - 5043078 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1


RefSeq NP_253193.1
GI 15599699
Affymetrix PA4503_at
Entrez 881080
GenBank AAG07891.1
INSDC AAG07891.1
NCBI Locus Tag PA4503
protein_id(GenBank) gb|AAG07891.1|AE004864_3|gnl|PseudoCAP|PA4503
UniParc UPI00000C5D3F
UniProtKB Acc Q9HVR8
UniRef100 UniRef100_A0A031CP50
UniRef50 UniRef50_B2T6W9
UniRef90 UniRef90_M4XC77


Feature Type CDS
Coding Frame 1
Product Name
dipeptide ABC transporter permease DppB
Product Name Confidence: Class 1
Evidence for Translation
Detected using LC-MS/MS (36.97 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 2.68
Kyte-Doolittle Hydrophobicity Value 0.656
Molecular Weight (kDa) 37.0
Isoelectric Point (pI) 8.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Vesicle Class 1
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 582 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004090 (537 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA4503
Search term: dppB

Transposon Insertions in PAO1

Type Confirmed ISphoA/hah insertion site
Mutant ID UWGC: 31946
Genomic Position 5042577
Position in ORF 510(1011)
Reference 14617778
Type Confirmed ISphoA/hah insertion site
Mutant ID UWGC: 32798
Genomic Position 5042370
Position in ORF 303(1011)
Reference 14617778

Transposon Insertions in Orthologs


Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.
Pletzer D, Lafon C, Braun Y, Köhler T, Page MG, Mourez M, Weingart H
PLoS ONE 2014 ;9(10):e111311
PubMed ID: 25338022