Pseudomonas aeruginosa PAO1, PA5389 (cdhR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5389
Name
cdhR
Replicon chromosome
Genomic location 6067005 - 6068015 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
CommentDeletion of cdhR results in a strain unable to grow using L-carnitine as a sole carbon source.;CdhR regulates the transcriptional induction of the adjacent PA5388 gene in response to L-carnitine.

Cross-References

RefSeq NP_254076.1
GI 15600582
Affymetrix PA5389_at
Entrez 880749
GenBank AAG08774.1
INSDC AAG08774.1
NCBI Locus Tag PA5389
protein_id(GenBank) gb|AAG08774.1|AE004951_8|gnl|PseudoCAP|PA5389
TIGR NTL03PA05390
UniParc UPI00000C5FDA
UniProtKB Acc Q9HTH5
UniProtKB ID CDHR_PSEAE
UniRef100 UniRef100_Q9HTH5
UniRef50 UniRef50_Q9HTH5
UniRef90 UniRef90_Q9HTH5

Product

Feature Type CDS
Coding Frame 1
Product Name
CdhR, transcriptional regulator
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 3.90
Kyte-Doolittle Hydrophobicity Value -0.135
Molecular Weight (kDa) 37.1
Isoelectric Point (pI) 9.00

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 402 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004948 (479 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5389
Search term: cdhR

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295