Pseudomonas syringae pv. tomato DC3000, PSPTO_2720 (nudC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas syringae pv. tomato DC3000 (Buell et al., 2003)
GCF_000007805.1|latest
Locus Tag
PSPTO_2720
NCBI Old Locus TagPSPTO2720
Name
nudC
Synonym: PSPTO2720
Replicon chromosome
Genomic location 3019482 - 3020318 (+ strand)
CommentExperimentally proven to be NADH hydrolase involved in regulation of redox homeostasis in P.syringae DC3000

Cross-References

RefSeq NP_792526.1
GI 28869907
Entrez 1184374
INSDC AAO56221.1
NCBI Locus Tag PSPTO_2720
NCBI Old Locus Tag PSPTO2720
UniParc UPI0000008CB6
UniProtKB Acc Q882A9
UniProtKB ID NUDC_PSESM
UniRef100 UniRef100_Q882A9
UniRef50 UniRef50_Q4KBL2
UniRef90 UniRef90_Q882A9

Product

Feature Type CDS
Coding Frame 1
Product Name
NudC
Product Name Confidence: Class 1
Synonyms mutT/nudix family protein
Evidence for Translation
Charge (pH 7) -11.26
Kyte-Doolittle Hydrophobicity Value -0.040
Molecular Weight (kDa) 31.0
Isoelectric Point (pI) 4.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 277 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003575 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSPTO_2720
Search term: nudC
Search term: NudC

Human Homologs

Ensembl 110, assembly GRCh38.p14
nudix hydrolase 13 [Source:HGNC Symbol;Acc:HGNC:18827]
E-value: 6.9e-27
Percent Identity: 35.4

References

NudC Nudix hydrolase from Pseudomonas syringae, but not its counterpart from Pseudomonas aeruginosa, is a novel regulator of intracellular redox balance required for growth, motility and biofilm formation.
Modzelan M, Kujawa M, Głąbski K, Jagura-Burdzy G, Kraszewska E
Mol. Microbiol. 2014 Sep;93(5):867-82
PubMed ID: 24989777