Pseudomonas aeruginosa UCBPP-PA14, PA14_01020 (hsiC1)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
Locus Tag
Synonym: tssC1
Replicon chromosome
Genomic location 99431 - 100927 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 8 transposon mutants in orthologs
CommentHcp Secretion Island-I-encoded type VI secretion system (H1-T6SS)


RefSeq YP_788241.1
GI 116053804
Entrez 4383502
INSDC ABJ15040.1
NCBI Locus Tag PA14_01020
UniParc UPI00000C4F25
UniProtKB Acc Q02UZ5
UniRef100 UniRef100_Q9I748
UniRef50 UniRef50_Q4K3N7
UniRef90 UniRef90_Q4K3N7


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -16.24
Kyte-Doolittle Hydrophobicity Value -0.428
Molecular Weight (kDa) 55.8
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5N8N STRUCTURAL PROTEIN 02/23/17 Contracted sheath of a Pseudomonas aeruginosa type six secretion system consisting of TssB1 and TssC1 Pseudomonas aeruginosa 3.28 ELECTRON MICROSCOPY 100.0

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 111 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000083 (1225 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA14_01020
Search term: hsiC1
Search term: HsiC1

Human Homologs


RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999
Coevolution of the ATPase ClpV, the sheath proteins TssB and TssC, and the accessory protein TagJ/HsiE1 distinguishes type VI secretion classes.
Förster A, Planamente S, Manoli E, Lossi NS, Freemont PS, Filloux A
J Biol Chem 2014 Nov 21;289(47):33032-43
PubMed ID: 25305017