Pseudomonas aeruginosa PAO1, PA4396

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4396
Name
Replicon chromosome
Genomic location 4925899 - 4926999 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentOverexpression of PA4396 impairs TTSS-mediated cytotoxicity

Cross-References

RefSeq NP_253086.1
GI 15599592
Affymetrix PA4396_at
Entrez 881332
GenBank AAG07784.1
INSDC AAG07784.1
NCBI Locus Tag PA4396
protein_id(GenBank) gb|AAG07784.1|AE004855_6|gnl|PseudoCAP|PA4396
TIGR NTL03PA04397
UniParc UPI00000C5CFB
UniProtKB Acc Q9HW10
UniProtKB ID Q9HW10_PSEAE
UniRef100 UniRef100_W0YZC4
UniRef50 UniRef50_W6R6I9
UniRef90 UniRef90_W0YZC4

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator
Product Name Confidence: Class 1
Synonyms probable two-component response regulator
Evidence for Translation
Charge (pH 7) -5.66
Kyte-Doolittle Hydrophobicity Value -0.033
Molecular Weight (kDa) 40.3
Isoelectric Point (pI) 5.48

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 574 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003986 (350 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4396

Human Homologs

References

Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution.
Pao GM, Saier MH Jr
J Mol Evol 1995 Feb;40(2):136-54
PubMed ID: 7699720
Sensor kinase PA4398 modulates swarming motility and biofilm formation in Pseudomonas aeruginosa PA14.
Strehmel J, Neidig A, Nusser M, Geffers R, Brenner-Weiss G, Overhage J
Appl Environ Microbiol 2015 Feb;81(4):1274-85
PubMed ID: 25501476