Pseudomonas aeruginosa PAO1, PA5261 (algR)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA5261
Name	algR
Replicon	chromosome
Genomic location	5922544 - 5923290 (- strand)
Transposon Mutants	3 transposon mutants in PAO1
Transposon Mutants in orthologs	1 transposon mutants in orthologs

Cross-References

RefSeq	NP_253948.1
GI	15600454
Affymetrix	PA5261_algR_at
DNASU	PaCD00008269
Entrez	877674
GenBank	AAG08646.1
INSDC	AAA18906.1
NCBI Locus Tag	PA5261
protein_id(GenBank)	gb|AAG08646.1|AE004938_8|gnl|PseudoCAP|PA5261
TIGR	NTL03PA05262
UniParc	UPI0000125856
UniProtKB Acc	P26275
UniProtKB ID	ALGR_PSEAE
UniRef100	UniRef100_P26275
UniRef50	UniRef50_P26275
UniRef90	UniRef90_P26275

Product

Feature Type	CDS
Coding Frame	1
Product Name	alginate biosynthesis regulatory protein AlgR Product Name Confidence: Class 1
Synonyms	AlgR1
Evidence for Translation	Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	0.87
Kyte-Doolittle Hydrophobicity Value	-0.124
Molecular Weight (kDa)	27.6
Isoelectric Point (pI)	7.28

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543 Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database	Victors : 4204
Category	Alginate regulation
Evidence	ECO:0000015 mutant phenotype evidence
Host Organism	Mus musculus
Notes
Reference	12379685
Source 2
Database	VFDB : VF0091
Category	Alginate regulation
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 618 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004842 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA5261 Search term: algR Search term: alginate biosynthesis regulatory protein AlgR

Human Homologs

References

AlgR-binding sites within the algD promoter make up a set of inverted repeats separated by a large intervening segment of DNA. Mohr CD, Leveau JH, Krieg DP, Hibler NS, Deretic V J Bacteriol 1992 Oct;174(20):6624-33 PubMed ID: 1400214

Control of mucoidy in Pseudomonas aeruginosa: transcriptional regulation of algR and identification of the second regulatory gene, algQ. Deretic V, Konyecsni WM J Bacteriol 1989 Jul;171(7):3680-8 PubMed ID: 2544550

The alginate regulator AlgR and an associated sensor FimS are required for twitching motility in Pseudomonas aeruginosa. Whitchurch CB, Alm RA, Mattick JS Proc Natl Acad Sci U S A 1996 Sep 3;93(18):9839-43 PubMed ID: 8790418